【摘要】 目的研究慢性阻塞性肺疾病(COPD)和肺原性心脏病(肺心病)患者不同中医证型胃肠动力障碍的临床表现及与胃肠激素、胃电图(EGG)、血气异常的关系。方法对120例COPD及肺心病患者进行中医辨证分型,检测血浆胃动素(MOT)、血浆血管活性肠肽(VIP)、血清胃泌素(GAS)、EGG及血气分析,并与26名健康人作对比。结果COPD和肺心病患者随病情加重胃肠功能障碍更明显,并由实证向虚证发展,虚证的EGG基本电节律降低最明显。痰湿壅肺证的MOT和GAS降低最明显;肺肾两虚证与肺脾肾均虚证的VIP均明显升高;肺脾肾均虚证缺氧及二氧化碳潴留最严重,其GAS反升高。结论COPD及肺心病患者均有不同程度的胃肠动力障碍及胃电图、胃肠激素异常;其通气功能障碍的程度、受损脏器的多少与病变的程度密切相关。更多还原

【Abstract】 Objective To study the correlations between the TCM syndromes of gastrointestinal dyskinesis and the disorders of gastrointestinal hormone,electrogastrogram(EGG) and blood gas in patients with chronic obstructive pulmonary diseases(COPD) and cor pulmonale.Methods The 120 cases of COPD and cor pulmonale were diagnosed with TCM syndrome differentiation,and plasma motilin(MOT),vasoactive intestinal peptide(VIP),Gastrin(GAS),EGG and blood gas were anglyzed and compared with 26 healthy subjects.Results With the aggravation of COPD and cor pulmonale,the dyskinesis of stomach and intestine was getting worse,developed from Shi-excess to Xu-deficiency.In deficiency syndrome,basic electrorhythm decreased most obviously.In phlegm-damp in lung syndrome,MOT and GAS decreased most obviously.In lung-kidney deficiency syndrome and lung-spleen-kidney deficiency syndrome,VIP increased most obviously.In lung-spleen-kidney deficiency syndrome,anoxia and carbon dioxide retention were most serious but GAS increased.Conclusion All patients of COPD and cor pulmonale have dyskinesis of stomach-intestine to a certain degree,abnormal EGG and disordered gastrointestinal hormones.Severity of ventilatory disturbance,quantity of injured organs,and condition of anoxia due to gastrointestinal blood stasis are all correlated with the development of COPD and cor pulmonale.更多还原