【摘要】 目的:优选制备山丹酮缓释片的最佳工艺。方法:分别以山楂总黄酮和丹参酮为考察指标,运用正交实验法优选;同时采用包合技术和亲水性骨架材料制备缓释片。结果:山楂总黄酮的最佳提取工艺为A2B2C1,丹参酮的最佳提取工艺为A3B1C2,制剂选用亲水性凝胶HPMC以及丙烯酸树脂为骨架材料。结论:经方差分析乙醇浓度和渗漉速度对提取效果有显著性影响,该缓释片的工艺和处方是合理可行的。更多还原

【Abstract】 Objective: To optimize the preparation of Shandantong sustained-release tablets.Methods: We used the orthogonal experiment to optimize the preparation and determined the contents of Shanzha total flavonoids and tanshinone.Involved technology and hydrophilicity skeleton materials were adopted to prepare the sustained-release tablets.Results: The best extracted progress of Shanzha total flavonoids and tanshinone were A2B2C1 and A3B1C2,respectively.The hydrophilicity skeleton materials were gel HPMC and acrylic resin.Conclusions: The concentration of alcohol and percolated speed are significant factors on the extracted efficacy by analysis of variance.The preparation and prescription of this sustained-release tablet is reasonable.更多还原