【摘要】 目的观察盐酸米多君对血液透析(HD)中低血压的疗效。方法选择呼伦贝尔市人民医院透析室维持血液透析患者21例,进行为期6周的盐酸米多君口服治疗。用药方法:于透析开始后1h服用米多君5mg。每次HD前、HD中、HD后测定患者血压、心率、观察患者的状况。每次HD前后测体质量、记录超滤量。症状及程度采用5分制评分,并于治疗前对比。结果与应用盐酸米多君前比较,患者HD中及HD后的最低收缩压、心率、总超滤量的差异有统计学意义(P<0.01)。盐酸米多君治疗HD中低血压显效4例(19.0%),有效8例(38.1%),进步6例(28.6%),总有效率为85.7%。头昏、胸闷、心悸等主要症状评分,盐酸米多君治疗后于治疗前比较差异有统计学意义(P<0.01)。无1例患者出现不良反应。结论盐酸米多君治疗HD中低血压安全有效。更多还原

【Abstract】 Objective To evaluate efficacy of midodrine in treatment of intradialysis hypotension(IDH)in maintenance hemodialysis patient(MDH).Methods21 MHD patients with IDH were given 1 hour after the beginning of hemodialysis,the treatment maintained for 6 weeks,if systolic blood pressure(SBP)increased less than 20 mm Hg.The pre-,intra-,post-hemodialysis blood pressure and heart rate,the pre-and post-hemodialysis body weight,the ultrafilitrated volume of each dialysis,the pre-and post-hemodialysis body weight,the ultrafiltrated volume of each dialysis,the pre-and post-treatment liver and renal function and electrocardiogram were measured and recorded.The symptoms of IDH were observed.ResultsCompared to those before treatment with midodrine hydrochloride,the minmum intradialysis SBP and heart rate at that time,the post-dialysis SBP and heart rate,and total ultrafiltrated changed significantly(P<0.01).The total effective rate was 85.7%.And the symptoms of IDH were improved significantly(P<0.01).No side effects were found in those patients.ConclusionMidodrine is safe and effective for the treatment of IDH更多还原