【摘要】 目的研究老年雌性大鼠性激素和骨生化标志物间的关系。方法选用18月龄老年大鼠作为老年性骨量降低模型,分析大鼠血清FSH、LH、P、E2水平和血清ALP,TrACP活性间的关系,并探讨了老年大鼠体内雌激素的来源问题。结果老年大鼠的动情周期时相与青年大鼠明显不同,性激素水平发生明显改变。FSH、LH可以独立于E2而直接对血清TrACP进行调节。结论骨生化指标和性激素水平有相关性。雌激素降低是引发这一调节过程的重要因素,老年大鼠非生殖系统雌激素所占比例增大。更多还原

【Abstract】 Objective To elucidate the relationship between sex hormone and bone markers in old female rats.Methods 18-month rats were used as a geriatric model which lost bone.We analyzed the level of FSH,LH,P and E₂ in serum.Then we connected the hormone level with the activity of serum ALP and serum TrACP to observe whether they are correlative.At last,we checked the source of E₂ in geriatric rats.Results The estrous cycle in geriatric rats are different from the adult,and the level of hormone takes on a dramatic change.FSH and LH can regulate TrACP in serum directly.Conclusions The bone markers are correlated with serum hormone,and this process is aroused by the low level of E₂.The percentage of E₂ from non-sex organ is bigger in geriatric rats than in adult.更多还原