【摘要】 目的:制备符合时辰药理学的硝苯地平缓释片。方法:用粉末直接压片法制备片芯,干压包衣技术制备缓释片。正交试验优选处方,对最优处方进行体外释放度验证。结果:脉冲缓释片延迟时间约5～6h,释放机制以骨架溶蚀起主导作用。结论:硝苯地平延迟起释型缓释片处方设计和工艺方法可行,质量稳定。更多还原

【Abstract】 Aim:To explore the preparation methods of nifedipine delayed-onset sustained-release tablets in accordance with chronopharmacology.Methods:Delayed-onset sustained-release tablets were prepared by direct compression of the powder mixture containing insoluble materials and coated using dry powder coating.The formulation was optimized by using the orthogonal design.Results:The lag time of the tablets was about 5-6 h.It was indicated that matrix erosion attribute to the major mechanism in the tablets release.Conclusion:We obtain the practical formulation and manufacturing processing of nifedipine delayed-onset sustained-release tablets and the tablet quality is stable.更多还原