【摘要】 目的探讨白细胞介素-2、维甲酸联合化疗治疗晚期非小细胞肺癌的近期疗效和不良反应。方法13例晚期非小细胞肺癌患者紫杉醇+顺铂(TP)方案化疗后白细胞介素-2皮下注射20万单位,2天1次;顺式-维甲酸20 mg,每天3次口服,评价疗效及不良反应。结果完全缓解(CR)1例,部分缓解(PR)6例,稳定(NC)5例,进展(PD)1例,总有效率(RR)为54%,主要的不良反应为恶心、呕吐和骨髓抑制等,12例为Ⅰ~Ⅱ度不良反应,患者耐受良好。结论白细胞介素-2、维甲酸联合TP方案化疗是一种对晚期非小细胞肺癌有效的治疗方案,不良反应轻,值得临床进一步研究应用。更多还原

【Abstract】 Objective To evaluate the efficacy and toxicity of the combination of chemotherapy with interleukin-2 and retinoic acid for advanced non-small cell lung cancer(NSCLC).Methods Thirteen NSCLC patients who had been treated by TP chemotherapy were subcutaneously injected 200 000 U interleukin-2 once per two days and 20 mg retinoic acid orally three times a day.The efficacy and side effects were assessed.Results Among the 13 patients,1 achieved complete response,6 achieved partial response,5 non-response and 1 had progressive disease.The overall response rate was 54%.The major toxicities included nausea,vomiting and marrow suppression.The incidence rate of severe toxicities was generally low and all the side effects were mild(gradeⅠ-Ⅱ) and well tolerated.Conclusion The combination of TP chemotherapy with interleukin-2 and retinoic acid is effective in treating advanced non-small cell lung cancer,and the adverse reaction is mild.更多还原