【摘要】 目的:研究三参提取物灌胃给药对大鼠肝纤维化的预防和治疗作用。方法:采用皮下注射四氯化碳(CCl4)和腹腔注射二甲基亚硝胺(DMN)诱导的2种大鼠肝纤维化模型,观察三参提取物对大鼠肝纤维化的影响。结果:三参提取物对2种肝纤维化大鼠有升高血清和肝脏中白蛋白(ALB)含量,降低血清中Ⅳ型胶原、总胆红素(TBiL)和肝脏中Hyp、丙二醛(MDA)含量,改善肝细胞损伤程度及肝纤维化、降低肝门静脉血压等作用。结论:三参提取物具有抗CCl4和DMN大鼠肝纤维化的作用,提示临床上可用于防治肝纤维化。更多还原

【Abstract】 Objective: To study precautionary and therapeutical effect of Sanshen extractive on hepatic fibrosis in rats. Methods: Two hepatic fibrosis models of rats induced by subcutaneous injection carbon tetrachloride(CCL4) and intraperitoneal injection dimethyl nitrosamine (DMN) were adopted,and the effects of Sanshen extractive on hepatic fibrosis were assayed. Results: Sanshen extractive could increase the ALB levels in serum and liver, lower the levels of type Ⅳ collagen and TBiL in serum, Hyp and MDA in liver,ameliorate hepatocyte injury and hepatic fibrosis, and reduce hepatic portal vein blood pressure etc. Conclusion: Sanshen extractive has anti-fibrosis effect in rats indicating that it can be used in prophylaxis and treatment of hepatic fibrosis in clinic.更多还原