【摘要】 目的:为了有效地减少由于胰岛素剂量不当发生的高/低血糖,探索基于药效动力学的餐前胰岛素用量算法。方法:基于已有的胰岛素药效学数据,采用插值和数值积分的方法来准确地计算出体内残余活性胰岛素量。结果:得到餐前所需补充的胰岛素用量算法并实现了计算机图形用户界面操作。结论:该算法可以使得治疗更加准确化和智能化,值得在临床上推广应用。更多还原

【Abstract】 Objective:To decrease hyperglycemia/glucopenia in diabetic patients induced by unsuitable dosage of insulin and to explore the arithmetic of pre-prandial insulin dosage based on pharmacodynamics.Methods:The remnant content of active insulin could be calculated well and truly by the interpolation method and the numerical integral,which based on the known data of insulin pharmaco- dynamics.Results:The arithmetic of preprandial supplementary insulin dosage was obtained and its graphical user interfaces (GUI) was implemented.Conclusions:This arithmetic could bring exact and intelligentialized therapy for diabetes and be recommendable in clinic.更多还原