【摘要】 目的:探讨慢性充血性心力衰竭患者血清胆红素(TBIL)水平与左心室功能的关系及其临床意义。方法:采用钒酸氧化法测定128例心力衰竭患者和63例对照组血清胆红素水平;用心脏彩色多普勒超声诊断仪测定并比较各组左室射血分数(LVEF)及左室舒张末期横径(LVEDD);同时进行6分钟步行实验(6MWT)。结果:心力衰竭患者血清胆红素显著高于对照组(P<0.01),而LVEF与6分钟步行距离(6MWD)较对照组明显减少(P<0.01),且心力衰竭患者随着心功能NYHA分级程度的加重血清胆红素水平及LVEDD逐步递增,LVEF与6MWD也相应减少,各亚组间比较仍有统计学差异(P<0.05)。血清胆红素水平与LVEDD呈正相关(r=0.78,P<0.01),而与LVEF呈负相关(r=-0.42,P<0.01)。结论:血清胆红素水平随着心力衰竭严重程度的增加而升高,并与左心室功能存在相关性,对慢性充血性心衰患者的诊断、病情及预后判断具有一定的临床意义。更多还原

【Abstract】 Objective:To explore the relationship between serum bilirubin concentration and left ventricular function and its clinical significance in patients with chronic congestive heart failure.Methods:The levels of serum bilirubin was assayed by means of vandate oxidation method in 128 cases with chronic heart failure and 63 cases of control group.The left ventricular ejection fraction (LVEF)and left ventricular end-diastolic diameter(LVEDD)were determined by color doppler ultrasonograph in those cases,and six-minutes walking test was carried out at the same time.Results:The levels of serum bilirubin in patients with chronic congestive heart failure were significantly higher than those in control group(P<0.01),and the LVEF and the 6MWD were both lower(P<0.01).The levels of serum bilirubin and the LVEDD were both increased with the severity of NYHA functional class,and the LVEF and 6MWD were both decreased.The levels of serum bilirubin were positively correlated with the LVEDD(r=0.78,p<0.01)and negatively with the LVEF(r=-0.42,P<0.01).Conclusion:The levels of serum bilirubin increased with the severity of chronic congestive heart failure in patients and had correlation with left ventricular function.There is an important clinical significance for the diagnosis,pathogenetic condition,and prediction in patients with chronic congestive heart failure.更多还原