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MAGE-A1、MAGE-C2及SSX-1在原发性肝细胞癌中的表达及意义

The expression of cancer-testis antigen MAGE-A1、MAGE-C2 and SSX-1 mRNA in hepatocellular carcinoma

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【作者】 蔡俊张富喜陈红松

【Author】 CAI Jun1,ZHANG Fu-xi,CHEN Hong-song(1 Affiliated Hospital of Beihua University,Jilin 132011,P.R.China)

【机构】 北华大学附属医院北京大学人民医院

【摘要】 目的检测肿瘤—睾丸抗原(CT抗原)MAGE-A1、MAGE-C2和SSX-1 mRNA在原发性肝细胞癌(HCC)中的表达情况。方法采用RT-PCR方法检测MAGE-A1、MAGE-C2和SSX-1 mRNA在55例HCC患者癌及癌旁组织中的表达,对产物进行测序,并对检测结果与临床指标进行分析。结果55例HCC患者的癌组织中,MAGE-A1、MAGE-C2和SSX-1 mRNA的表达率分别为60.0%、14.5%和40.0%;癌旁组织无表达。结论CT抗原MAGE-A1、MAGE-C2和SSX-1 mRNA在HCC中呈高表达,是HCC免疫治疗的理想靶位。

【Abstract】 Objective To investigate the expression of MAGE-A1,MAGE-C2 and SSX-1 mRNA in hepatocellular carcinoma.Methods Reverse-transcription polymerase chain reaction(RT-PCR) was used to investigate the mRNA expression of the three cancer-testis antigens(MAGE-A1,MAGE-C2 and SSX-1) in patients with HCC.PCR products of cancer-testis antigens were sequenced.The correlation between the expression of cancer-testis antigen and clinical parameters was analyzed.Results In 55 patients with HCC,the rate of MAGE-A1,MAGE-C2 and SSX-1 mRNA expression was 60.0%,14.5% and 40.0%,respectively.However,mRNAs of these CT antigen were not detected in the adjacent non-cancerous tissues.Conclusion MAGE-A1,MAGE-C2 and SSX-1 mRNAs are expressed with high percentages in HCC,indicating that they may be candidates for antigen-specific immunotherapy targets in HCC.

【基金】 教育部2007年度“新世纪优秀人才支持计划”项目(985-2-099-113);863项目(2007AA021103)
  • 【文献出处】 山东医药 ,Shandong Medical Journal , 编辑部邮箱 ,2008年45期
  • 【分类号】R735.7
  • 【被引频次】3
  • 【下载频次】65
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