【摘要】 不使用溶剂,室温下通过对对氯苯甲醛、频哪酮和碱的研磨即可合成出4,4-二甲基-1-(4-氯苯基)-1-戊烯-3-酮。考察了碱的种类、氢氧化钠的用量、频哪酮的用量和反应时间等因素对反应的影响,确定了适宜的合成工艺条件:研磨时间20 min,对氯苯甲醛∶频哪酮∶氢氧化钠为1.0∶1.1∶0.5(摩尔比)。在此条件下的产品收率96.2%,含量为99.1%。该方法反应条件温和,操作简便。同时,作为催化剂的碱可重复使用。更多还原

【Abstract】 4,4-Dimethyl-1-(4-chlorophenyl)-1-pentene-3-one was synthesized from p-chlorobenzaldehyde, pinacolone and basic by grinding under solvent-free conditions at room temperature. The effect of the type of basic, the amount of sodium hydroxide, the amount of pinacolone and reaction time were investigated in this article. The results showed that the optimum condition of synthesis are followed: rubbing time 20 min, n(p-chlorobenzaldehyde): n(pinacolone): n(hydroxide)=1.0:1.1:0.5. Yield was 96.2% and the purity achieved 99.1%. The method have convenient operation and mild reaction conditions . At the same time, as a catalyst for the base can be recovered and reused.更多还原