【摘要】 目的研究双氯芬酸钠胶浆剂直肠给药在家兔体内的药动学。方法24只家兔随机分为2组,每组12只(♀♂各半),分别直肠给予双氯芬酸钠胶浆剂和栓剂(3mg·kg-1),按试验方案采血,采用HPLC法测定血药浓度。结果双氯芬酸钠胶浆剂组tmax为12.60min,ρmax为8.39mg·mL-1(P<0.001);双氯芬酸钠栓剂组tmax为94.46min,ρmax为5.62mg·mL-1(P<0.001)。结论双氯芬酸钠胶浆剂直肠给药后血药峰浓度高,且达峰时间短,优于双氯芬酸钠栓剂直肠给药。更多还原

【Abstract】 AIM To study the pharmacokinetics of diclofenac sodium mucilage in rabbits.METHODS Twenty-four rabbits(12 male and 12 female)were randomly divided into two groups.Twelve rabbits in diclofenac sodium mucilage group(3 mg·kg-1)were given with rectal administration and 12 rabbits in diclofenac sodium suppository group(3 mg·kg-1)were given with rectal administration.Blood samples were collected according to the test program and the serum concentrations of diclofenac sodium were measured.RESULTS The values of tmax were 12.60 min and 94.46 min(P<0.001),ρmax were 8.39 mg·L-1 and 5.62 mg·L-1(P<0.001),with diclofenac sodium mucilage group and diclofenac sodium suppository group.CONCLUSION The ρmax is high and tmax is quick of diclofenac sodium mucilage than that of diclofenac sodium suppository,with ractal administration.更多还原