【摘要】 以四正丁基溴化铵(TBAB)作相转移催化剂,7-羟基香豆素(1)或7-羟基-4-甲基香豆素(2)与5种卤代烃经Williamson反应合成了10个新的7-烷氧基香豆素,其结构经1H NMR,IR和MS表征。Williamson反应的优化条件为:以丙酮为溶剂,在碘化钾存在下,1或25mmol,n(1或2)∶n(卤代烃)∶n(碳酸钾)∶n(TBAB)=1.0∶1.5∶2.5∶0.1,于60℃～100℃反应5h～8h,产率84%～96%。更多还原

【Abstract】 Ten novel 7-alkoxylcoumarins were synthesized by Williamson reaction of 7-hydroxycoumarin(1) or 7-hydroxy-4-methylcoumarin(2) and five alkyl halides using tetrabutylammonium bromide(TBAB) as a phase transfer catalyst. The structures were characterized by 1H NMR, IR and MS. Optimum conditions of Williamson reaction in acetone in presence of KI at 60 ℃~80 ℃ for 5 h~8 h were as follows: 1(or 2) was 5 mmol; n(1 or 2) ∶n(alkyl halide) ∶n(K2CO3) ∶n(TBAB)=1.0 ∶1.5 ∶2.5 ∶0.1. The yields were 84%~96% under the optimum conditions.更多还原