【摘要】 目的分析毛细支气管炎发展为哮喘的高危因素。方法采用回顾性研究和临床随访的方法,选取280例住院治疗的毛细支气管炎患儿为研究对象。其中男207例,女73例。就患儿性别,是否进行大剂量静脉用免疫球蛋白(IVIG)治疗、是否按时接种卡介苗(BCG)、喂养方式、特应性体质和哮喘家族史等调查和分析。结果毛细支气管炎患儿280例发展为哮喘82例,发生率为29.29%,显著高于国内城区普查数据(0.12%~3.34%)。大剂量IVIG组,按时接种BCG组,无特应性体质患儿,无哮喘家族史患儿及母乳喂养儿哮喘发生率均显著低于非大剂量IVIG组,未按时接种BCG组,特应性体质患儿、哮喘家族史患儿及非母乳喂养儿(P<0.01)。结论毛细支气管炎患儿具有特应性体质和哮喘家族史是哮喘发生、发展的高危因素,而接受大剂量IVIG治疗,及时接种BCG及母乳喂养对哮喘发生有保护作用。更多还原

【Abstract】 Objective To analyze the risk factors of asthma in children with bronchiolitis.Methods Two hundred and eighty children with bronchitis were chosen and tread,207 males,and 73 femals.The review research and clinical revisits were carried out to investigate and analyze the subjects in terms of sex,whether receiving high-dose of intravenous injection immunoglobulin(IVIG) treatment or not,where getting vaccinated with bacilli calmette guerin(BCG) as planed or not,the way of feeding,where having the atopy physique and asthma family history or not,and so on.Results The rate of asthma was 29.29%(82/280) and remarkably highter than the domestic urban survey data(0.12%~3.34%).The incidence of asthma was significantly lower in children with administering the large dose of IVIG,vaccinating BCG vaccine as planed,having no atopy physique,having no asthma family history and breast feeding than those without administering the high-dose of IVIG,vaccinating BCG vaccine as planed,brest feeding,with atopy physique and asthma family history(P<0.01).Conclusion In children with bronchiolitis,atopy physique and asthma family history are high risk factors to the development and occurrence of asthma;while high-dose of IVIG treatment,BCG Vaccination as planed and breast feeding only may take on protection against the occurrence of asthma.更多还原