【摘要】 目的:观察非小细胞肺癌(NSCLC)组织中表皮生长因子受体(EGFR)和血管内皮生长因子(VEGF)的表达,并探讨二者可能的临床意义。方法:免疫组织化学染色比较82例NSCLC和20例非恶性肺组织中EGFR和VEGF的表达;观察NSCLC患者不同临床病理特征下EGFR和VEGF蛋白的表达情况,并分析二者表达的相关性。结果:NSCLC组织中EGFR、VEGF阳性表达率明显高于非恶性肺组织(53.66%vs0,62.20%vs25%,P<0.05)。EGFR表达在不同性别、不同病理类型(鳞癌vs腺癌)、有无淋巴结转移及不同TNM分期的NSCLC患者之间有统计学差异(P<0.05);VEGF表达在有无淋巴结转移及不同TNM分期的NSCLC患者之间有统计学差异(P=0.0001)。EGFR、VEGF高表达患者生存期短于各自的低表达患者(P<0.05)。NSCLC组织中EGFR和VEGF的表达具有相关性(rs=0.314,P<0.05)。结论:NSCLC组织中EGFR和VEGF存在过度表达,二者表达具有相关性,可作为判断NSCLC患者病情及预后的参考指标和靶向治疗靶点。更多还原

【Abstract】 Objective:To observe the expression of epidermal growth factor receptor(EGFR)and vascular endothelial growth factor(VEGF)in non-small cell lung cancer(NSCLC),and to discuss its clinical significance.Methods:The expression of EGFR and VEGF was detected in 82 NSCLC and 20 non-malignant pulmonary samples by immunohistochemical method.The expression of EGFR and VEGF in NSCLC patients with various pathological characteristics was observed and the correlation between them was analyzed.Results:The positive rates of EGFR and VEGF in 82 NSCLC samples were obviously higher than those in the 20 non-malignant samples(53.66% vs 0 for EGFR,62.20% vs 25% for VEGF,both P<0.05).The expression of EGFR in NSCLC samples was significantly correlated with the sex of patients,pathological types of cancer(squamous-cell carcinoma vs adenocarcinoma),presence of lymph node metastasis,and TNM stages(P<0.05).The expression of VEGF in NSCLC was correlated with lymph node metastasis and TNM stages(P<0.05).It was also noticed that higher expression of EGFR or VEGF was associated with poor prognosis of patients(P<0.05).The expression of EGFR was correlated with VEGF expression in pulmonary tissues of NSCLC patients(rs=0.314,P<0.05).Conclusion:EGFR and VEGF are over-expressed in NSCLC tissues and the 2 are correlated with each other,which may serve as predicator for prognosis and a therapeutic target of NSCLC patients.更多还原