【摘要】 目的探讨宫颈神经内分泌肿瘤(NTC)的临床病理特征、诊断鉴别诊断及其生物学行为。方法对5例NTC进行光镜、电镜、免疫组化观察分析、随访及文献复习。结果瘤组织呈弥漫性或片团状浸润,瘤细胞体积小,圆形、卵圆形或短梭形,胞质少,核深染,分裂象多见,每例均有坏死。2例可见菊形团样结构。免疫组化瘤细胞表达CK、低分子量CK(35βH11),5例瘤细胞均表达CgA、Syn及NSE。电镜观察到菊形团样结构及神经内分泌颗粒。5例NTC中2例为非典型类癌,3例为小细胞癌,2例伴鳞癌分化,1例伴腺癌分化。结论宫颈NTC的组织形态类似于肺的NTC,除典型类癌外,其恶性程度高,预后差。诊断宫颈神经内分泌癌必须两项以上神经内分泌标记物阳性或电镜观察到神经内分泌颗粒。病理诊断应与子宫颈内膜间质肉瘤、非霍奇金淋巴瘤及小细胞型低分化鳞癌等鉴别。免疫组化及电镜对这些肿瘤的鉴别诊断很有帮助。更多还原

【Abstract】 Objective To investigate the clinicopathological features,diagnosis And differential diagnosis of neuroendocrine tumor of the cervix(NTC),and its behaviour.Methods Five cases of NTC were studied by microscopy,electron microscopy and immunohistochemistry.Clinical follow-up was performed and related literature was reviewed.Results Histopathologically,the tumor was composed of small,round,oval and spindle cells with scant cytoplasm,hyperchromatic neclei in solid sheets and diffuse features.Numerous mitotic figures and extensive necrosis were common finding.The foci of squamous cell carcinoma or adenocarcinoma were identified in 3 cases.Ultrastructurally,a rosettes finding and neuroendocrine granule were found.Immunohistochemically,five cases stained positive for at least two neuroendocrinic markers,such as CgA,Syn and NSE.Conclusion NTC is a rare and highly malignant tumor but caicinoid.NTC has a poor prognosis and early metastases.Its morphology resemble small cell carcinoma in the lung.The differential diagnosis of NTC includes endometrial stromal sarcoma,non-Hodigin lymphoma and poorly differentiated squamous cell carcinoma by characteristed small cell.Immunohistochemistry and electron microscopy is useful in diagnosis of NTC.更多还原