【摘要】 目的:检测类胰岛素生长因子1(IGF-Ⅰ)基因微卫星多态性CA重复与食管鳞状细胞癌是否关联。方法:应用荧光标记片段分析法对78例食管鳞状细胞癌患者和470例正常对照进行基因分型,并用非条件性Logistic回归分析微卫星多态性与食管鳞状细胞癌的关联性。结果:IGF-Ⅰ基因微卫星多态性CA重复与食管鳞状细胞癌的发病没有关联。结论:IGF-Ⅰ基因微卫星多态性CA重复在食管鳞状细胞癌的发病过程中不起主要作用。更多还原

【Abstract】 Objective: To investigate the relationship between a microsatellite polymorphism(CA repeats) in the insulin-like growth factor I gene and the risk of esophageal squamous cell carcinoma.Methods: IGF-Ⅰ microsatellite polymorphism was genotyped among 78 cases with esophageal squamous cell carcinoma and 470 normal controls by fluorescent labeled fragment analysis.And data were analyzed using unconditional logistic regression to evaluate the association of examined polymorphism with esophageal squamous cell carcinoma.Results: No association was found between IGF-Ⅰ microsatellite polymorphism and esophageal squamous cell carcinoma.Conclusion: IGF-Ⅰ microsatellite polymorphism(CA repeats) does not play a major role in the development of esophageal squamous cell carcinoma.更多还原