【摘要】 目的:探讨儿童间变性大细胞淋巴瘤的临床表现、组织病理及免疫组化的特点。方法:对2001年—2006年收集的4例儿童间变性大细胞淋巴瘤进行临床资料分析、病理形态学观察及免疫表型检测。结果:4例患者临床表现主要为浅表淋巴结肿大,发病迅速且伴不规则发热及肝脾肿大;组织学特征是淋巴结结构破坏,上皮样大细胞浸润淋巴窦,瘤细胞较大,细胞核偏位,形态多样,类似马蹄形、肾形。患者的肿瘤细胞均表达ALK-1、EMA和K i-1。结论:对儿童间变性大细胞淋巴瘤中ALK-1、K i-1、EMA的表达情况检测有助于诊断和鉴别诊断。更多还原

【Abstract】 Objective:To study the clinical manifestations and histopathological and immunohistochemical features of anaplastic large cell lymphoma(ALCL) in children.Methods:We analyzed the clinical data,performed pathological examination,and tested the immunophenotypes of four ALCL children who were admitted in our hospital from 2001 to 2006.Results:The main clinical manifestations included enlarged superficial lymphnodes,rapid development disease,irregular fever,and hepatosplenomegaly.Morphological examination showed that the normal structure of lymphnode was destroyed and the large cells infiltrated into lymphnode sinuses.The tumor cells had large size with eccentric,horseshoe or kidney-shaped nucleus.Immunohistochemical analysis showed that the tumor cells positively expressed activin receptor-like kinase-1(ALK-1),epithelial membrane antigen(EMA),and Ki-1.Conclusion:Detection of the expression of ALK-1,Ki-1,and EMA in ALCLs will provide assistance for diagnosis and differential diagnosis of ALCLs.更多还原