【摘要】 目的:研究复方当归汤中阿魏酸在兔体内的药物动力学规律。方法:采用兔按4ml·kg^-1单次灌胃给予复方当归汤,于不同时间点取样,不测定血浆中阿魏酸浓度,并用3P87软件处理药物动力学参数。采用RP-HPLC测定血药浓度,以甲醇-水（0.3%冰醋酸）（40:60）为流动相,Zorbax SBC₁₈（150 mm×4.6 mm,5μm）,紫外检测波长323 nm。结果:兔口服复方当归汤的血浆药-时曲线表现为单峰二室模型,主要药物动力学参数如下:Ka(min^-1)=0.1400,K₂₁=1.5×10^-2,K₁₀=1.1×10^-2,K₁₂=3.4×10^-2,t_1/2α（min）=12.05,t_1/2β（min）=224.45,t_1/2γ（min）=5.11,C_max(ng·ml^-1)=73.20,AUC(ng·min^-1·ml)= 1.082×10⁴,CL/F（s）(L·min^-1)=3.700×10^-4,V/F（c）(ng·ml^-1)=3.2×10^-2。结论:复方当归汤的体内有效成分阿魏酸吸收分布呈二室模型。更多还原

【Abstract】 Objective:To study the pharmacokinetic parameter of ferulic acid of Compound Angelica Sinensis solution in rabbits. Method:Compound Angelica Sinensis Solution was ig by 4 ml·kg^-1 in tabbits.The concentrations of ferulic acid in plasma at different time points were detected.And the pharmacokinetic porameters were obtocined by 3P87 software package.Zorbax SBC₁₈（150nn×4.6 mm,5μm） was used to detect the concerntration and methanol-water（containing 0.3% acetic acided）（40:60） was the mobile phase and UV detetion was at 323 nm.Result:The main pharmacokinetic parameters of Ferulic acid were as follows:Ka(min^-1)=0.1400, K₂₁=1.5×10^-2,K₁₀=1.1×10^-2,K₁₂=3.4×10^-2,t_1/2α（min）=12.05,t_1/2β（min）=224.45,t_1/2γ（min）=5.11,C_max(ng·ml^-1) =73.20,AUC(ng·min^-1·ml)=1.082×10⁴,CL/F（s）(L·min^-1)=3.700×10^-4,V/F（c）(ng·ml^-1)=3.2×10^-2.Conclu- sion:The absorption and the metabolism of FA in Compound Angelica Sinensis solution is fitted with two-compartment model.更多还原