【摘要】 为了检识国产鸭跖草(Commelina communis L.)药材中多羟基生物碱类α-糖苷酶抑制剂成分,采用水提取、醇沉淀,再经离子交换树脂和葡聚糖LH20层析等步骤从鸭跖草中提取、富集和纯化总碱部位;采用离子阱电喷雾离子化质谱(ESIMS)检测总生物碱中多羟基生物碱成分。从安徽绩溪产鸭跖草药材中检识到文献报道的多羟基生物碱成分,并可能提示存在文献未报道的其他多羟基生物碱类成分。研究结果表明国产鸭跖草药材含有多羟基生物碱类α-糖苷酶抑制剂,可用于糖尿病治疗和保健使用。更多还原

【Abstract】 For detecting polyhydroxyalkaloids-type α-glucosidase-inhibiting ingredients of Commelina communis L.grown in China,total alkaloids were obtained from the plant by extraction with water,removal of precipitation after the addition of alcohol,enrichment and purification by ion exchange resin and sephadex LH 20 chromatography.Polyhydroxyalkaloids in the total alkaloids were detected by ion trap electron-spray ionization mass spectra(ESIMS).Several reported and unreported polyhydroxyalkaloids in the plant were detected from the material collected from Jixi county,Anhui province.The crude drug growing in China contains α-glucosidase-inhibiting polyhydroxyalkaloids and can be used to therapy in diabetes.更多还原