【摘要】 目的:合成1β-甲基碳青霉烯抗生素CS-834。方法:以单环β-内酰胺起始原料,经过合成双环、侧链及连接得到目标化合物CS-834。结果:目标化合物CS-834经红外光谱、核磁共振氢谱、质谱确证其化学结构,总收率为22．1％。结论:本方法原料易得,反应条件温和,操作简单。更多还原

【Abstract】 Objective:To synthesize carbapenem CS-834.Methods:Using monocyclic 1β- lactam as a starting agent,CS-834 was synthesized via several steps including substitution,side chain coupling and intermolecule Witting reaction.Results:The chemical structure of the CS-834 was con- firmed by IR,MS and ~1H-NMR.Conclusion:This mild and easily manipulated synthetic procedure was attainable.更多还原