【摘要】 目的:制备两亲性的N-正辛基-N′-琥珀酰基壳聚糖(OSC)胶束,并研究其制剂学特征。方法:采用超声方法制备OSC胶束,并考察OSC的胶束化行为、胶束的形态、粒径及ξ电位。结果:OSC胶束具有较低的临界胶束浓度,胶束粒子呈较规则的球形,粒径为200～250 nm,ξ电位在-40.0～-30.0 mV,且疏水链段取代度增加,粒径变大,临界胶束浓度降低。结论:OSC胶束具有较好的物理稳定性。更多还原

【Abstract】 Objective:To prepare N-octyl-N′-succinyl chitosan micelles.Methods: N-octyl-N′-succinyl chitosan micelles were prepared by ultrasonication and were characterized in regard to micellization,morphology,particle size,and zeta potential.Results:N-octyl-N′-succinyl chitosan micelles had lower critical micelle concentration.The particles of the micelles showed a spherical shape with a diameter of 200~250nm and zeta potential of-40.0~-30.0mV.The degree of substitution of alkyl chain to the N-octyl-N′-succinyl chitosan was positively proportion to the particle size of N-octyl-N′-succinyl chitosan micelles but inversely to the critical micelle concentration values of N-octyl-N′-succinyl chitosan.Conclusion:N-octyl-N′-succinyl chitosan micelles have favorable physical stability.更多还原