【摘要】 目的探讨慢性丙型肝炎患者自身抗体检测的临床意义。方法应用ELISA方法检测117例慢性丙型肝炎患者血清中自身抗体,并比较其与HCVRNA、肝硬化发生率、年龄、性别的关系。结果117例慢性丙型肝炎患者中有55例至少有1项自身抗体阳性,总阳性率为47.00%,明显高于健康对照组(6.66%,P<0.01)。HCVRNA阳性组与HCVRNA阴性组自身抗体的检出率无显著性差异(P>0.05)。自身抗体阳性组中丙型肝炎肝硬化发生率(40/55)明显高于自身抗体阴性组(31/62)(P<0.01)。自身抗体阳性组中≥40岁的患者比例明显高于自身抗体阴性组(P<0.05)。两组间性别比较,差异无统计学意义。结论慢性丙型肝炎患者中普遍存在自身免疫现象,自身抗体的检出率与患者的年龄和肝硬化发生率明显相关。在常规诊疗中检测自身抗体,对于慢性丙型肝炎患者的诊断和治疗具有一定的指导意义。更多还原

【Abstract】 Objective To investigate the clinical significance of autoantibodies detection in patients with chronic hepatitis C.Methods Sera from 117 consecutive patients with chronic hepatitis C were investigated for the presence of autoantibodies by ELISA, and the correlations with HCV RNA, cirrhosis, age, and gender.Results 55 of 117(47.00%) patients were positive for at least one autoantibody. The positive rates were much higher than that of healthy control (P<0.01). Distribution of the autoantibodies showed no differences between HCV RNA positive and negative groups (P>0.05). The cirrhosis prevalence rate in autoantibody positive group (40/55) were significantly higher than that of negative group (31/62)(P<0.01). The number of patients aged ≥40 in autoantibody positive group were much more than that of negative group (P<0.05). There was no significant difference between males and females in autoantibody positive rate.Conclusion The autoimmune manifestations are existed commonly in patients with chronic hepatitis C. The positive rate of autoantibody is correlated with age and cirrhosis.Detection of autoantibodies routinely may be help diagnosis and treatment of chronic hepatitis C patients.更多还原