【摘要】 目的检测子痫前期-子痫患者肝功能指标尤其是血浆中纤维连接蛋白(FN)的变化,探讨子痫前期-子痫患者肝脏损伤的情况及FN在其改变中的作用。方法以59例子痫前期-子痫患者作为研究对象,分为轻度子痫前期及重度子痫前期/子痫两组,选择正常非妊娠妇女22例及正常孕晚期妇女35例作为对照组,检测各组妇女血浆中FN、丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、总蛋白(TP)、白蛋白(ALB)、碱性磷酸酶(ALP)、总胆红素(TBIL),直接胆红素(DBIL)进行统计学分析。结果FN:子痫前期-子痫组较正常非孕组升高(P<0.05),较正常孕晚期升高(P<0.01);轻度子痫前期组较正常孕晚期升高(P<0.05),与正常非孕组差异无统计学意义(P>0.05);重度子痫前期/子痫组较正常非孕组及正常孕晚期组增高(P<0.01),较轻度子痫前期升高,差异有统计学意义(P<0.05)。肝功:ALT、AST:子痫前期-子痫组较正常孕晚期升高(P<0.05);重度子痫前期/子痫组较正常非孕组及正常孕晚期组增高(P<0.01)。TP、ALB:正常孕晚期较正常非孕组降低(P<0.01);子痫前期-子痫组较正常非孕组及正常孕晚期降低(P<0.01);轻度子痫前期及重度子痫前期/子痫组均较正常非孕组及正常孕晚期降低,差异有统计学意义。ALP:正常孕晚期、子痫前期-子痫组、轻度子痫前期及重度子痫前期/子痫组较正常非孕组升高(P<0.01);子痫前期-子痫各组与正常孕晚期组比较,差异无统计学意义(P>0.05)。TBIL、DBIL:未见明显变化。重度子痫前期/子痫组与轻度子痫前期组ALT、TP比较,差异有统计学意义(P<0.01),AST比较,差异有统计学意义(P<0.05)。结论随着病情的发展,子痫前期-子痫患者出现了不同程度的肝脏损伤;FN既可作为肝脏损伤的重要指标之一,又可能提示在肝脏损伤及修复过程中可能起到一定的作用。更多还原

【Abstract】 Objective To investigate the changes of plasma fibronectin(FN) and the liver function in the patients of preeclampsia-eclampsia.Methods FN、ALT、AST、TP、ALB、ALP、TBIL、DBIL were examined in 59 patients with preeclampsia-eclampsia divided into mild pre-eclampsia and severe preeclampsia-eclampsia,comparing with 35 normal late-pregnancy women、22 non-pregnancy women.Results FN:The FN in patients with preeclampsia-eclampsia is higher than non-pregnancy women(P<0.05) and normal late-pregnancy women(P<0.01);FN in mild preeclampsia is higher than normal late-pregnancy women(P<0.05);FN in severe preeclampsia-eclampsia is higher than non-pregnancy women and normal late-pregnancy women(P<0.01),the same to comparing with mild preeclampsia(P<0.05).ALT、AST:preeclampsia-eclampsia is higher than normal late-pregnancy women(P<0.05);TP、ALB: normal late-pregnancy women is lower than non-pregnancy women(P<0.01);preeclampsia-eclampsia is lower than non-pregnancy women and normal late-pregnancy women(P<0.01);ALP: normal late-pregnancy women、preeclampsia-eclampsia、mild pre-eclampsia、severe preeclampsia-eclampsia are higher than non-pregnancy women;Changes between each group of preeclampsia-eclampsia and normal late-pregnancy women have no statistical significance(P>0.05).The ALT and TP in severe preeclampsia-eclampsia has statistical changes comparing with mile preeclampsia(P<0.01),the same to AST(P<0.05).Conclusion With the development of preeclampsia-eclampsia,the patients have liver disfunction.FN can be one of markes to examine the liver disfuntion and appears to be useful in the injury and reconditioning of liver.更多还原