【摘要】 目的:探讨甲亢患者血清CG测定在评价甲亢性肝功能损害中的价值。方法:采用RIA方法测定50例健康志愿者及195例甲亢患者血清CG水平,并对谷丙转氨酶(ALT)进行同步检测,进行对比分析。结果:血清CG水平:甲亢初诊组与未缓解组明显高于对照组及甲亢治愈组(P<0.01),甲亢未缓解组明显高于初诊组(P<0.01),甲亢治愈组与对照组无显著性差异(P>0.05);CG的改变与ALT改变一致,且血清CG水平与甲状腺激素水平具有良好的相关性(相关系数为0.91)。结论:血清CG是评价甲亢性肝功能损害敏感而特异的指标。其增高的水平与甲亢病情及病程呈正相关。更多还原

【Abstract】 Objective:To study the clinical value of measurement of serum cholyglycine(CG)in the patients with hyperthyroidism to evaluate thyrotoxic hepatic damages.Methods:The levers of serum CG and ALT of 50 healthy volunteers(as control group)and 195 patients with hyperthyroidism were measured by radioimmunassay(RIA).Results:Serum CG levels in the patients with hyperthyroidism(including the preliminary diagnosis group and unrelieved group)were distinctly higher than those in control group and cured hyperthyroidism group(P<0.01);it was distinctly higher in unrelieved group than that in preliminary diagnosis group with hyperthyroidism(P<0.01),and there was no distinct difference between the control group and cured hyperthyroidism group in serum CG(P>0.05).The change of serum CG was accordant with ALT.There was favourable correlation between the serum CG and serum thyroxine.Conclusion:Serum CG is a sensitive and specific index to evaluate the thyrotoxic hepatic damages,and the level of serum CG is correlative with the disease course and the level of serum thyroxine.更多还原