【摘要】 目的探讨喉癌中血管内皮生长因子C(Vascularendothelialgrowthfactor-C,VEGF-C)的表达与淋巴道转移的关系。方法免疫组化SP法,对54例喉癌组织行VEGF-C检测及癌周组织毛细淋巴管计数,应用全自动图像分析仪对染色结果进行定量测定,以平均灰度值表示VEGF-C的染色强度。结果喉癌组织内VEGF-C表达高于声带息肉(P<0.05);颈淋巴结转移组高于非转移组(P<0.01)。癌周组织毛细淋巴管密度高于对照组正常喉组织(P<0.01);颈淋巴结转移组高于非转移组(P<0.01)。喉癌组织内VEGF-C表达与癌周组织淋巴管密度呈正相关(r=0.603,P<0.01)。结论喉癌组织中VEGF-C的表达与癌周毛细淋巴管密度关系密切,VEGF-C高表达促进淋巴管增殖,促进淋巴道转移。更多还原

【Abstract】 Objective:To investigate the relationship of the expression of VEGF-C and the metastasis of the lymphoid nodes in laryngeal cancer.Methods:Using immunohistochemistry method, the expression of VEGF-C in the tumor tissues and the density of lymphatic in adjacent tissue of laryngeal carcinoma were detected.Results:The expression of VEGF-C in laryngeal carcinoma was higher than in vocal cord polyp and in lymphoid node-positive was higher than in node-negative. Density of lymphatic capillary in adjacent tissue of laryngeal carcinoma was much higher than in normal laryngeal tissue and in lymphoid node-positive was higher than in node-negative.Conclusion:VEGF-C protein expression is close to lymphatic metastasis.更多还原