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Design and implementation of an optical simulation environment for bioluminescent tomography studies

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【Author】 LI Hui, TIAN Jie, LUO Jie, LU Yujie, CONG Wenxiang and WANG Ge ( Department of Education Technology, Capital Normal University, Beijing 100037, China; Key Laboratory of Complex Systems and Intelligence Science, Institute of Automation, Chinese Academy of Sciences, Beijing 100080, China; Bioluminescent Tomography Laboratory, Department of Radiology & Department of Biomedical Engineering, University of Iowa, Iowa City, Iowa 52242, USA)

【摘要】 <正>As a challenging task for bioluminescent tomography simulation, a virtual optical environment is needed to solve the forward problem accurately, that is, to achieve a high precision for bioluminescent signal synthesis on the external body surface of a small animal. The molecular optical simulation environment named MOSE is implemented using the C++ programming language and the OpenGL techniques, including a user-friendly interface with interactive tools facilitating users’ operations. The accuracy of the virtual optical environment is verified by error analysis of mesh simplification and comparison between MOSE results and experimental data. This virtual optical environment is accurate, flexible and efficient to simulate the photon propagation in complicated tissues, which has a great potential to become a software platform for bioluminescent tomography studies and other molecular imaging applications.

【Abstract】 As a challenging task for bioluminescent tomography simulation, a virtual optical environment is needed to solve the forward problem accurately, that is, to achieve a high precision for bioluminescent signal synthesis on the external body surface of a small animal. The molecular optical simulation environment named MOSE is implemented using the C++ programming language and the OpenGL techniques, including a user-friendly interface with interactive tools facilitating users’ operations. The accuracy of the virtual optical environment is verified by error analysis of mesh simplification and comparison between MOSE results and experimental data. This virtual optical environment is accurate, flexible and efficient to simulate the photon propagation in complicated tissues, which has a great potential to become a software platform for bioluminescent tomography studies and other molecular imaging applications.

【关键词】 molecular imaging； biolumlnescent tomography； photon propagation； Monte Carlo method.；
【Key words】 molecular imaging； biolumlnescent tomography； photon propagation； Monte Carlo method.；
【基金】 Supponed by National Natural Science Fundation for Distinguished Young Scholars of China(Grant No．60225008);National Natural Science Foundation of China(Grant Nos．30500131,90209008,30370418,60302016);the National Institutes of Health,USA(Grant No．EB001685)
  • 【文献出处】 Progress in Natural Science ,自然科学进展(英文版) , 编辑部邮箱 ,2007年01期
  • 【分类号】Q-334
  • 【被引频次】4
  • 【下载频次】40
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