【摘要】 目的分析人工肝支持系统(ALSS)留置静脉导管相关性感染(CRI)的临床、病原学特点,探讨防治措施。方法对行ALSS治疗的肝衰竭患者留置静脉导管尖端和外周血进行细菌学培养及药物敏感试验。结果61例CRI中共分离出64株病原菌,其中革兰阳性菌56株、革兰阴性菌2株、真菌6株,最常见的是凝固酶阴性葡萄球菌,该菌对万古霉素敏感率100%。结论及时拔除感染导管是防治CRI的有效方法,临床应以预防为主,万古霉素是治疗CRI的首选药物。更多还原

【Abstract】 OBJECTIVE To analyze clinical and etiologic characteristics of indwelling venous catheter-related infection(CRI) in artificial liver support system(ALSS)-treated patients and explore the measures of prevention and treatment.METHODS Bacterial culture and drug sensitivity test were performed in cusp of catheters after being pulled out and the peripheral blood in liver failure patients.RESULTS Sixty four strains were isolated including 56 Gram-positive strains,2 Gram-negative strains and 6 fungi ones,respectively.The most frequent organism was Staphylococcus epidermidis which had high sensitivity to vancomycin.CONCLUSIONS The most effective measure is removing catheters in time,and vancomycin is the most optimal agent for CRI.更多还原