【摘要】 目的:探讨头皮针埋线治疗帕金森病的作用机制。方法:建立大鼠帕金森病模型,随机分为模型组、头针组、药物组,并设立正常组。头针组选取"百会"旁"舞蹈震颤麻痹区"埋线,药物组用L-dopa制成悬浮液灌胃。治疗30d后,进行行为学观察;检测脑组织丙二醛(MDA)、一氧化氮(NO)含量和超氧化物歧化酶(SOD)活性。结果:头皮针埋线能使模型大鼠脑组织中MDA的含量显著降低(P<0·01),NO的含量显著增加(P<0·05),SOD的活性无明显差异(P>0·05);其行为学和脑组织形态学方面均有明显改善。结论:头皮针埋线对帕金森病大鼠体内抗氧化酶系统具有调整作用,对脑组织细胞形态具有明显的改善作用。更多还原

【Abstract】 Objective To explore the mechanism of scalp catgut embedding for treatment of Parkinson′s disease. Methods Parkinson′s disease model rats were prepared, and randomly divided into a model group, scalp acupuncture group, medication group, with a control group set up. The scalp acupuncture group were treated with catgut embedding at "the chorea-trembling conroued area" lateral to "Baihui" (GV 20) and the medication group with intragastric perfusion of L-dopa suspension. After treatment for 30 days, behavior indexes were investigated and malondialdehyde (MDA) and nitric oxide (NO) contents and superoxide dismutase (SOD) activity in the brain were detected. Results MDA content in the brain of the model rats were significantly decreased (P<0.01), NO level significantly increased (P<0.05) by scalp catgut embedding, with no significant change of SOD activity (P>0.05); and the behavior indexes and tissue and form of the brain had significant improvement. Conclusion Scalp catgut embedding has regulative action on anti-oxidant enzyme system in the Parkinson′s disease rats, has significant improvement of cells, tissues and form of the brain.更多还原