【摘要】 目的:探讨意外伤害及事故倾性的家族聚集性,为将来阐明遗传因素在其中的作用提供初步线索。方法:以事故倾性儿童为先证者,采用病例对照研究方法研究579个核心家系(291个先证家系和288个对照家系),分析意外伤害及事故倾性的家族聚集性。结果:病例组有36.4%核心家系至少有一名成员发生过伤害,高于对照组9.0%,差异有统计学意义。病例组的父、母、同胞伤害发生率均高于对照组(差异有显著性)。但病例组与对照组一级亲属的事故倾性发生率无显著性差异。多因素Logistic回归分析发现,父、母、同胞发生伤害都是儿童事故倾性的危险因素,儿童喜欢冒险、不能集中精力也和事故倾性有关联。结论:意外伤害存在家族聚集性,遗传因素可能在其中发挥一定作用。没有发现事故倾性具有家族聚集性。更多还原

【Abstract】 Objective:To explore familial aggregation in unintentional injury and accident-proneness,and search clues for elucidating genetic effects.Methods:Accident-prone children were selected as probandes,and a case-control study including 579 nuclear families(291 cases and 288 controls) was carried out to analyses the family aggregation of unintentional injury and accident-proneness.Results:36.4% families of cases’ included at least one family member occurred injury,which was significantly higher than that of controls’(9.0%).The injury prevalence of the first-degree relatives in cases was significantly higher than that noticed in controls.However,prevalence of accident-proneness showed no significance.Occurrences of injury among father,mother,and siblings were significantly associated with accident-proneness by multivariate logistic regression analysis.Preferring risk taking and attention deficit were risk factors of accident-proneness also.Conclusion:Occurrence of unintentional injury appears in family aggregation,and genetic factor may contribute to this disease.However,accident-proneness dose not appeared in family aggregation.更多还原