【摘要】 目的测定血管性痴呆（VD）与非痴呆脑血管病（NDCVD）患者及健康老年者血清叶酸、Vitamin B₁₂水平,同时评估认知功能的变化,分析并探讨其在VD的可能作用。方法选择VD40人,为痴呆组;NDCVD40人,为非痴呆组;同期选定40名健康老年人作为对照组。应用MMSE对3组对象的认知功能进行评定,测定被试着血清叶酸、Vitamin B₁₂水平。初步观察补充叶酸、Vitamin B₁₂对VD认知功能的影响。结果3组血清叶酸、Vitamin B₁₂水平（以中位数M及95%的可信区间CI表示）,以VD组最低为4.20ng/ml（4.07～5.50）、343.67pg/ml（296.54～413.73）。与对照组比较有显著性（P<0.01）,VD与NDCVD组相比叶酸水平不同（P<0.01）,而Vitamin B₁₂水平无差别（P>0.05）。3组MMSE值VD组最低（16.05±5.94）,各组之间明显不同（P<0.01）。初步显示补充叶酸、Vita- min B₁₂对VD患者认知功能有一定的改善作用。结论VD患者血清叶酸、Vitamin B₁₂水平明显低于健康者,低水平叶酸、Vitamin B₁₂可能对VD的认知功能有影响。更多还原

【Abstract】 Objective The serum folic acid and Vitamin B₁₂ were determined in patients of vascular dementia （VD）,non-dementia cerebrovascular disease（NDCVD） and the healthy senile.Cognitive status was evaluated by using mini mental state examination （MMSE）,The effect of folic acid and Vitamin B₁₂on VD and its cognitive func- tion were analyzed.Methods 80 patients were selected.Group distributions:VD （40） and NDCVD （40）.Forty healthy senile were selected at random as the control group.The patients were evaluated by MMSE and folic acid and Vitamin B₁₂were determined.Result Serum foliate and Vitamin B₁₂levels in VD group were lowest in the three groups.The median and 95%CI were 4.20ng/ml （4.07～5.50）,343.67pg/ml（296.54～413.73）.There was sig- nificant difference in VD compared with the control group （P<0.01）,same difference of serum folic acid in VD comparing with NDCVD（P<0.01）,and no difference of serum Vitamin B₁₂was found in VD and the NDCVD（P>0.05）.Scores of MMSE in VD（16.05±5.94）were significantly higher than NDCVD and the control group.There was striking difference in three groups （P<0.01）.Supplement of folic acid and Vitamin B₁₂possibly improve VD pa- tients’cognitive function.Conclusion Serum folic acid and Vitamin B₁₂ level in VD were significantly lower in the three groups.Folic acid and Vitamin B₁₂ of low concentration are possible risk factors on VD and it’s cognition.更多还原