【摘要】 目的临床上耐多药肺结核患者治疗效果往往不佳。探讨手术联合化疗治疗耐多药肺结核患者的疗效。方法对1995年4月—2005年3月住院的48例采用外科手术治疗+化疗的耐多药肺结核患者进行分析。肺部有空洞病变36例(75%),双侧肺均有病变16例(33.3%)。手术方式包括肺叶切除28例,全肺切除15例,胸膜全肺切除3例,肺段切除1例,楔形切除1例。结果术后死亡率2.1%(n=1)。并发症发生率16.7%(n=8)。术后随访6～90个月。痰菌阴转率83.3%。结论耐多药肺结核患者若有良好的心肺功能储备,手术治疗安全有效,配合化疗能提高患者的治愈率。更多还原

【Abstract】 Objective The outcome of chemotherapy treatment in treating multidrug-resistant pulmonary tuberculosis(MDR-TB) is not satisfied,thus the study is to explore the feasibility of surgery combined with chemotherapy in treating MDR-TB.Methods A retrospective review was performed in 48 MDR-TB patients who had surgery combined with chemotherapy from April,1995 to March,2005.36 patients(75%) had cavitary lesions,16 patients(33.3%)had bilateral lesions.All patients received pulmonary resection,consisting of lobectomy(n=28),pneumonectomy(n=15),pleuropneumonectomy(n=3),segmentectomy(n=1),wedge resection(1).Results Mortality was 2.1%(n=1) after surgery.Postoperative complications occurred in 8 patients(16.7%).The follow up was ranged from 6 to 90 months.Sputum conversion rate was 83.3%.Conclusion Pulmonary resection combined with chemotherapy achieves high cure rates with acceptable morbidity and mortality.更多还原