【摘要】 目的:探讨重组IL-11在临床的应用现状及存在的问题,以期为临床合理用药提供参考。方法:对我院两例使用rhIL-11后发生严重渗漏综合征的病例进行报道分析。结果及结论:两例患者经停药及加用地塞米松后症状明显缓解,且胸腹水未经穿刺引流而消失。故在较大强度化疗骨髓抑制期使用巨和粒是否更易出现渗漏综合征有待于临床进一步的研究证实。更多还原

【Abstract】 OBJECTIVE: To discuss the application of recombinate IL-1 and problems in its use for references of its rational administration in the clinic. METHODS: 2 patients who developed severe leaky syndrome after the administration of recombinant IL-1 collected in our hospital were reported and analyzed. RESULTS & CONCLUSION: Symptoms in 2 cases were significantly relieved with the use of dexamethasone and after discontinuation of recombinate IL-1, and pleural fluid and ascites were disappeared without drainage, therefore, it remains to be confirmed in the further studies whether leaky syndrome would more often occur in patients receiving high intensity chemotherapy after treatment with macrophage & granulocyte stimulating growth factors at bone marrow depression stage.更多还原