【摘要】 苯基重氮盐分别与4种硝基化合物的钠盐在冰水浴下反应得到4种α-硝基腙,产率为66％～89％;硝基腙与伯胺在回流条件下反应3 h,在相转移催化条件下用亚硝酸钠氧化2～3 h,得到9种新的3,5-二取代-1-苯基-1,2,4-三唑衍生物,产率为54％～71％;所有化合物的结构均经1H NMR、IR和元素分析确证。更多还原

【Abstract】 Benzenediazonium chloride reacted with the solutions of the sodium salts of four nitro compounds in an ice-bath to provide fourα-nitrohydrazones in yields of 66%～89% , then the a-nitrohydrazones were refluxed with primary amine for 3 h, the resulting mixtures were oxidized with sodium nitrite for 2～3 h in the presence of TEBAC to afford nine novel 3,5-disubstituted-1-phenyl-1 ,2,4-triazole derivatives in 54%～71% yields. All the target compounds were characterized by means of 1H NMR, IR and elemental analysis. This synthetic strategy widens the application of a-nitrohydrazones and enriches the methodology for the synthesis of triazole derivatives. The methodolgy also has advantages such as common available materials, mild reaction conditions and high yields.更多还原