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多效胃镜乳的处方改进及稳定性考察

Improvement and stability of multi-effect gastroscope emulsion

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【作者】 杨政于西全晏明

【Author】 YANG Zhen~1 YU Xi-quan~2 YAN Ming~3 (1.Department of Pharmacy,Fujian Provincial Hospital,Fuzhou 350001,China;2.Department of Pharmacy,Fuzhou General Hospital,Nanjing Military Region,Fuzhou 350025,China;3.The Second Military Medical University Shanghai 200433,China)

【机构】 福建省立医院药剂科南京军区福州总院药剂科第二军医大学 福建 福州 350001福建 福州 350025学员上海 200433

【摘要】 目的:改进多效胃镜乳的处方,提高多效胃镜乳的稳定性,控制制剂的质量。方法:通过外观质量、显微镜检、离心试验、耐寒耐热试验、常温留样以及含量测定等为指标,考察不同的乳化剂对多效胃镜乳质量的影响,确定最优处方。结果:以0.8%司盘-80、1.6%西黄蓍胶和5%司盘-80、2%CMC-Na配制的多效胃镜乳,稳定性好。结论:改进后的多效胃镜乳处方可应用于制剂生产。

【Abstract】 Objective:To enhance the stability and control quality of the multi-effect gastroscope emulsion by improving the pre- scription of emulsion.Methods:The different prescriptiones of the multi-effect gastroscope emulsion were tested and evaluated by mi- croscopy,centrifugal experiment,cold-resistant/heat-resistant experiment,room temperature storage test as well as the content-determi- nation.Results:The emulsion with 0.8% span-80,1.6% tragacantha or with 5% span-80,2% CMC-Na has a good stability.Conclu- sion:The prescriptions of the multi-effect gastroscope emulsion can be applied to preparation production.

  • 【文献出处】 药学实践杂志 ,Journal of Pharmaceutical Practice , 编辑部邮箱 ,2007年01期
  • 【分类号】R944
  • 【被引频次】5
  • 【下载频次】51
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