【摘要】 目的观察联合两种引流方法并腔内注入高聚生治疗恶性胸膜腔积液的疗效。方法160例肿瘤合并恶性胸积液的患者分为两组,治疗组(持续引流+常规引流)86例,对照组(持续引流)74例,引流后注入高聚生,最多3次,4周后评价疗效。结果治疗组和对照组总有效率分别为93.0%和85.1%,无显著性差异(p>0.05),完全缓解率分别为82.5%和62.2%,有显著性差异(p<0.01),不良反应有胸痛、发热、渗漏、导管脱落、堵塞,除导管堵塞发生率有统计学差异(p<0.01),其他指标两组间比较无显著性差异(p>0.05)。结论联合两种引流法腔内注入高聚生,可提高完全缓解率,是彻底控制恶性胸积液的有效方法。更多还原

【Abstract】 Objective To evaluate the therapeutic effects of infusing highly agglutinative staphylococcin (HASL) combining two draining ways. Methods 160 patients were randomized into two groups, 86 in the experimental group (traditional and lasting effusion),74 in the control group(lasting effusion),all the patients were infused HASL into pleural after draining. Results The response rate was 93.0% for the experimental group and 85.1% for the control group. There were no significant differences between the two groups (p>0.05).The complete remission was 82.5% for the experimental group and 62.2% for the control group, which was statistically significantly different (p<0.01).The adverse effects were chest pain, fever, seepage, vessel falling off and block. There were no significant differences between two groups except block. Conclusion Infusing HASL into pleural cavity combined with traditional and lasting draining way may be a better way to control malignant pleural effusion.更多还原