【摘要】 目的:介绍骨髓移植供者行骨髓采集术过程中麻醉方法的选择,分析其麻醉效果。方法:应用计算机检索中文科技期刊数据库1994-01/2006-12期间与骨髓移植和麻醉相关的文献,检索词“骨髓移植、麻醉”,限定文章语言种类为中文。对资料进行初审,并查看每篇文献后的引文,文献所述内容应与骨髓移植、骨髓采集术麻醉方法的选择、处理及效果相关,且以近5年发表在较权威杂志者优先。排除重复性文章及Meta分析类文章。结果:共检索到52篇相关文献,通过阅读摘要或全文对其内容进行分类整理,19篇符合纳入标准。骨髓移植术是目前根治血液系统恶性疾病及某些遗传性疾病的主要手段之一,如何顺利地采集供者骨髓、同时又能最大程度地保障其安全一直是人们十分重视的问题。采集骨髓时麻醉方法的选择及其效果关系到供者的生命安全,具体方法包括连续硬膜外麻醉、全身麻醉、局部麻醉3种。19篇文献报道了783例骨髓移植供者行骨髓采集时的麻醉方法,其中以连续硬膜外麻醉为主,占93.49%,局部麻醉占5.87%,全身麻醉占0.64%。结论:骨髓移植供者行骨髓采集术时,相对全身麻醉、局部麻醉而言,采用连续硬膜外麻醉法简便易行、用药单纯,对供者的生理干扰不大,又可达到麻醉和手术的要求,对循环、呼吸功能影响小,临床上具有一定的优越性。更多还原

【Abstract】 AIM:To introduce the anesthetic method selection during bone marrow collection for the donor of bone marrow transplantation, and analyze the anesthetic effects. METHODS:A computer-based online search of Chinese Technological Periodicals Database was undertaken to identify the Chinese articles about bone marrow transplantation and anesthesia dated from January 1994 to December 2006 with the Key words of "bone marrow transplantation, anesthesia" in Chinese. The data were firstly selected and the quotation after each article was looked over. The articles concerning to bone marrow transplantation and the selection, manipulation and effects of anesthetic method in bone marrow collection operation were chosen to the study, especially published in recent 5 years. Repeated articles and Meta analysis were excluded. RESULTS: Totally 52 articles were collected from the above-mentioned database, after the abstract or full text was read through and arranged, 19 were accorded with the inclusive criteria. Bone marrow transplantation is one of the most important measures to approach radical cure of blood system malignant tumor and some genetic diseases. How to collect the bone marrow from the donor safely, and protect them is the focus that has attracted much attention. The anaesthetic method selection and its effect could directly influence the life safety of donors. The methods include continuous epidural anaesthesia, general anaesthesia, and local anaesthesia. Among the 783 donors reported in 19 articles who underwent bone marrow collection, continuous epidural anaesthesia was accounted for 93.49%, local anaesthesia for 5.87%, and general anaesthesia for 0.64%. CONCLUSION: During bone marrow collection operation, continuous epidural anaesthesia is easy and simple, and has little interference to circulation and breath of donors. Therefore, it is superior to general anaesthesia and local anaesthesia to certain extent in clinic.更多还原