【摘要】 研究了豆类丝核菌次级代谢产物对小鼠后代的行为致畸作用。将5组孕鼠分为空白对照组、豆类丝核菌次级代谢产物低剂量组、中剂量组、高剂量组及阳性对照组,分别灌胃给予生理盐水、低剂量(SW含量3.54 mg/kg)、中剂量(SW含量14.15 mg/kg)、高剂量(SW含量56.62 mg/kg)豆类丝核菌次级代谢产物及10 mg/kg环磷酰铵(CP),待其自然分娩后,观察其后代生长发育及行为状态。结果表明,豆类丝核菌次级代谢产物3个剂量组在反射能力、协调运动能力、学习记忆能力及自主活动能力各方面指标与空白对照组相比差异均不显著(P>0.05),而与阳性对照组相比差异极显著(P<0.01)。在本实验的剂量和条件下,豆类丝核菌次级代谢产物对小鼠后代不具有行为致畸作用。更多还原

【Abstract】 To study the effect of the secondary metabolites of Rhizotonia Leguminicola on behavioral teratogenesis in mice.All the gestationed mice were divided into five experimental groups randomly,negative control group(normal saline),positive control group(10 mg/kg Cyclophosphamide(CP)),high dosage group(containing SW 56.62 mg/kg),medium dosage group(containing SW 14.15 mg/kg) and low dosage group(containing SW 3.54 mg/kg).Early physiological functions and behavioral functions of their filial mice were observed.No significant differences were observed between the three secondary metabolites of Rhizotonia Leguminicola group and negative control group in the reflectance,coordinated motion ability,retention and autonomic activities(P>0.05),but have significant differences to positive control group(P<0.01).The secondary metabolites of Rhizotonia Leguminicola have no behavioral teratological effects under the experimental conditions.更多还原