【摘要】 目的:研究食管癌组织中血管内皮生长因子(VEGF)的表达对树突状细胞(DC)的影响。方法:对94例食管癌组织采用辣根过氧化物酶(HRP)标记的链霉亲和素-生物素法(LSAB),分别检测VEGF、S100蛋白的表达水平,并分析VEGF与S100+DC的相关性。结果:食管癌组织中VEGF的表达率为74.46%(70/94),VEGF的表达与患者的临床分期及癌组织的分化呈正相关(r=0.864,0.803,P<0.05)。临床分期越晚,病癌组织的分化越低,癌组织内S100+DC的密度越小(r=-0.763,-0.908,P<0.05)。随着癌组织内VEGF表达量的上升,S-100+DC的密度降低,二者呈负相关(r=-0.817,P<0.05)。结论:食管癌组织中VEGF的表达可降低S100+DC的密度,从而影响机体的免疫功能。更多还原

【Abstract】 AIM: To investigate the relationship between vascular endothelial growth factor (VEGF) and S100 protein positive dendritic cell (DC) in esophagelal tumor tissue. METHODS: VEGF and S100 protein in 94 patients with esophageal carcinoma were detected by HRP Labelled streptavidin biotin(LSAB) immunohistochemical method. RESULTS: Postive rate of VEGF in esophageal tumor tissues was 74.46%(70/94); and the later the clinical stage and the lower the differentiation level was the more VEGF was(r=0.864, 0.803, respectively; P<0.05 ); while the later the clinical stage and the lower the differentiation level was, the less number of S100~+DCs existed (r=-0.763, -0.908 , respectively; P<0.05). Furthermore, there was a reverse correlation between the expression of VEGF and S100~+ DC (r=-0.817, P<0.05). CONCLUSION: There may be a reverse relationship between the expression of VEGF and S100~+ DC in esophageal tumor tissue, VEGF could decrease the number of S100~+ DC and impair the immunological function of the body.更多还原