【摘要】 目的观察不同质量浓度11,12-EET对心肌缺血/再灌注损伤的影响及给药后不同时间11,12-EET保护作用的变化,以期了解11,12-EET对心肌保护作用的特点。方法复制大鼠心脏缺血/再灌注模型,给予不同浓度的11,12-EET,观察不同时间点的心功能变化。结果给予6.24×10-7.5mol/L、6.24×10-8mol/L 11,12-EET均可改善心肌缺血/再灌注损伤的大鼠心功能,6.24×10-9mol/L 11,12-EET作用较弱;给药24 h后11,12-EET拮抗大鼠心肌缺血/再灌注损伤的作用也减弱。结论11,12-EET的浓度及给予11,12-EET的时间对心脏保护作用有一定的影响。更多还原

【Abstract】 Objective To study the protective effects of 11,12-EET on ischemia/reperfusion heart in rat at different times.Methods The ischemia/reperfusion rat model was established by coronary artery ligation and reperfusion,and 11,12-EET were given at different times and in different concentrations to monitor the ±dp/dtmax of rat heart.Results 6.24×10-7.5mol/L,6.24×10-8mol/L and 6.24×10-9mol/L 11,12-EET given before the establishment of ischemia showed certain protective effects on ischemia/reperfusion in rat heart function;6.24×10-8mol/L 11,12-EET given 24 h before the establishment ischemia/reperfusion however,showed no significant protective effect.Conclusion 11,12-EET have protective effects on ischemia/reperfusion heart in rat.更多还原