【摘要】 采用新型分子模版吸附树脂动态吸附、丙酮解吸、水稀释结晶和丙酮重结晶等流程,从红色链霉菌发酵滤清液中分离红霉素,研究影响吸附分离效率的各种因素,并与现行醋酸丁酯萃取生产流程比较。结果显示,改性LX-18树脂对红霉素的吸附量达130 ku/mL,对发酵液中色素的选择分离率>95%,红霉素浓度120~150 ku/mL的丙酮解吸液采用水稀释结晶,再用丙酮重结晶,即获得各项理化指标达药典标准的红霉素。结晶母液须2次吸附回收,红霉素总收率为60%~62%。本工艺具有简便、分离成本较低和减轻废水污染的特点。更多还原

【Abstract】 Useing neotype resin development-absorbing,acetone-desorption,water diluting to crystallize and acetone-recrystallisation separate the Erythromycin from red streptomycete fermentation scrubber liquid.Study all kinds of influence factors and compare with currently butylacetate-abstraction production flow-sheet.The result shows that the new reshaping resin LX-18 does so well in absorbing the Erythromycin,its adsorption quantity reach 130 ku/mL and the separation for pigmentosus >95%,the Erythromycin concentration by 120～150 ku/mL of acetone-desorption liquid use water diluting to crystallize,then acetone-recrystallisation.After that,it’s all physical and chemical indicatrix can gain the pharmacopoeia standard.The crystal mother liquid need to twice adsorbing-recover,and the total yield of Erythromycin can reach 60%～62%.This separation method possesses simple process,high efficiency,low cost and only mild pollution wastewater.更多还原