【摘要】 目的了解鲍曼不动杆菌(Acinetobacter baumanmii,Aba)医院感染现状及其对临床常用抗菌药物的耐药情况,以指导临床更有效地使用抗生素。方法按常规方法对住院病人的各种临床标本进行细菌培养和分离,VITEK-II全自动微生物鉴定仪进行鉴定,按当年度CLSI的标准用纸片扩散(K-B)法对临床常用的抗菌药物进行药物敏感性试验,采用whonet5.3软件对数据进行统计处理。结果共分离出161株Aba,主要来源于痰、咽拭子、分泌物及血,分别占68.9%(111/161)、10.6%(17/161)及7.5%(12/161);Aba分布居前3位依次为ICU占30.4%(49/161)、呼吸内科占16.1%(26/161)和神经内科占13.7%(22/161);其对17种常用抗生素的耐药率为亚胺培南11.8%、美诺培南8.1%,对头孢他啶、头孢吡肟、左氧沙星的耐药率均小于50.0%,而对其余抗菌药物耐药率均在50.0%以上。结论Aba院内感染部位主要为呼吸道。Aba对大多数临床常用抗生素呈现出多重耐药,亚胺培南及美诺培南是治疗该菌感染最为有效的药物。更多还原

【Abstract】 Objective To survey the nosocomial infection and antibiotic-resistant of Acinetobacter baumannii. Methods Strains of Acinetobacter baumannii were isolated and cultured in routine procedures,and identified by VITEK-II.Antibiotic Susceptibility Test(AST) were conducted by disc-diffusion(K-B) method,the results were determined according to guidelines from NCCLS(National Committee Clinical Laboratory Standards).And whonet 5.3 software were used to deal with the data. Results There 161 Acinetobacter baumannii strains were detected,mainly isolated from the spucutum(68.9%,111/161),the secrecion(10.6%,17/161) and the blood prepration(7.5%,12/161).The first three sites of distribution of Acinetobacter baumannii were ICU(30.4%,49/161),department of respiratory(16.1%,26/161)和department of neurology(13.7%,22/161).Among 17 antibiotics frequently used,the resistant rate of Acinetobacter baumannii to imipenem was 11.8%,and 8.1% to Meropenem,and the resistance to ceftazidime,cefepime and levofloxacin was <50.0%,but exceeded 50.0% to all the other agents. Conclusion Acinetobacter baumannii is multi-resistant to most antimicrobial agents.Imipenem and Meropenem are the two most effective drugs for treatment of Acinetobacter baumannii infection.更多还原