【摘要】 目的通过观察稳定期不同级别慢性阻塞性肺病患者血清TNF-α、IL-8、GM-CSF水平与FVC、FEV1和FEV1/FVC关系,探讨血清TNF-α、IL-8、GM-CSF水平的变化对FVC、FEV1、FEV1/FVC的影响及其机制。方法在呼吸科门诊筛查的COPD患者中选取56例分为1组、2组和3组,分别检测FVC、FEV1、FEV1/FVC;用ELISA方法测定患者血清中TNF-α、IL-8、GM-CSF水平;另从患病1,2,3组中抽出10名患者为治疗1T、2T、3T组;对选定的治疗组患者口服百令胶囊30d后,检测相同指标。结果TNF-α、IL-8、GM-CSF水平在不同级别中存在差异(P<0.05),与FEV1,FVC存在着明显的负相关(P<0.05)。结论COPD细胞因子的持续升高是引起肺组织慢性损伤、功能降低的重要原因。更多还原

【Abstract】 Objective To to explore the change of serum TNF-a, IL-8, GM-CSF level in different grade and their effect on FVE1, FVC, FEV1/FVC of COPD patients in stable stage by observing the levels of tumor necrosis factor (TNF-a), interleukin-8(IL-8), granulocyte macrophage colony stimulating factor (GM-CSF) in the serum of chronic obstructive pulmonary disease (COPD) patients in different stable grade, and their lung function, including forced vital capacity(FVC), forced expiratory volume one second(FEV1), FEV1/FVC, as well as the relationship between these factors and lung function after treated Methods A total of 56 COPD patients from the respiratory clinic, were divided into Group 1, Group 2 and Group 3 based on GOLD grading standard. The levels of FVC, FEV1, FEV1/FVC were determined. Ten patients were randomly chosen from the three groups served as Treatment Group1, 2 and 3, the levels of FVE1, FVC, FEV1/FVC were determined, while the levels of TNF-a,IL-8,and GM-CSF in serum were determined 30 days after orally adminstration of Bailing capsule. Results The levels of FEV1, FVC, FEV1/FVC are significantly different in various grades (P<0.05). The levels of TNF-α, IL-8, and GM-CSF were nagatively correlated with that of FEV1 and FVC. Conclusion The continuous increase of COPD cytokine is an important cause resulting in the chronic lesions in pulmonary tissues and the lowerig of pulmonary function.更多还原