【摘要】 目的了解湖南省一般人群中戊型肝炎病毒感染状况,为湖南省戊肝防制提供基本的依据。方法采用酶联免疫法检测一般人群血清标本抗-HEV IgM和IgG抗体。结果8个县(市、区)1,553名一般人群血清抗-HEV IgM和IgG抗体平均阳性率分别为0.32%、21.70%,8个县(市、区)一般人群抗-HEV IgG抗体阳性率差异较大,从最低为0至最高达70.73%;无论是全部8个县(市、区)还是4个抗-HEV IgG抗体阳性率高的县(市、区),一般人群中男、女性抗-HEV IgG抗体阳性率差异无显著性,且随着年龄的上升而上升。结论湖南省部分地区可能曾发生过戊肝爆发,但由于戊肝疫情监测的敏感性较低而未能及时发现。今后应加强对戊肝的监测和科学研究力度,掌握戊肝疫情变化动态和流行病学特征,降低戊肝发病率。更多还原

【Abstract】 Objective To understand the infectious status of hepatitis E virus(HEV) in general population of Hunan Province and provide a scientific basis for controlling the disease. Methods IgM and IgG Antibodies against HEV were detected with enzyme-linked immenosorbent assays(ELISA). Results The average positive rates of IgM and IgG against HEV were 0.32% and 21.70% in 1,553 persons in 8 counties(cities,districts).The average positive rates of IgG varied greatly in 8 counties(cities,districts),from 0 up to 70.73%;There were no significant differences between male and female in IgG positive rates,and the IgG positive rates were increased along with the increase of age. Conclusion The outbreak of hepatitis E might have occurred in some areas without being detected due to lower sensitiveness of monitoring,detection and capability.Thus in-depth study and monitoring of hepatitis E be strengthened in the future in order to reduce incidence of hepatitis E.更多还原