【摘要】 目的:研究核内不均一核糖核蛋白A2/B1(heterogeneous nuclear ribonucleoprotein A2/B1,hnRNP A2/B1)在正常子宫内膜、子宫内膜异位症(EMs)患者在位内膜、患者异位内膜间的表达差异。方法:用免疫组织化学法和Western blot分析,研究3例增生中晚期正常子宫内膜、3例增生中晚期EMs患者的在位内膜和异位内膜中,hnRNP A2/B1蛋白的表达差异。结果:hnRNP A2/B1主要表达于间质和腺上皮细胞的细胞核内,且EMs患者在位内膜和异位内膜中的表达强度,均低于正常内膜中的表达(P<0.05);而患者在位内膜和异位内膜中的表达,无明显差异(P>0.05)。结论:hnRNP A2/B1可能参与EMs的发生和发展。更多还原

【Abstract】 Objective:To study the different expression of heterogeneous nuclear ribonucleoprotein A2/B1(hnRNP A2/B1)among normal endometria,eutopic and ectopic endometria of patients with endometriosis.Methods:The expression differences among three normal proliferate-stage endometria,three proliferatestage eutopic and ectopic endometria of patients with endometriosis was examined by immunohistochemistry and Western blot.Results:hnRNP A2/B1 was located in the nucleus of both epithelial glands and stroma.The expression level of hnRNP A2/B1 in ectopic and eutopic endometria of patients with endometriosis both were weaker than that in normal endometria(P < 0.05),while the difference between ectopic and eutopic endometria in the patients was not significant(P > 0.05).Conclusion:hnRNP A2/B1 may play an important role in the pathogenesis of endometriosis.更多还原