【摘要】 目的探讨立体定向多靶点手术治疗难治性精神病失败的原因及二次手术的治疗效果。方法对18例已行立体定向多靶点手术治疗的难治性精神病患者,手术效果欠佳,分析原因,结合第一次手术靶点及目前核心症状,再次在立体定向基础上,进行杏仁核、内囊前肢、扣带回、隔核等多靶点组合,进行核团射频热凝手术治疗。应用CGI、WISC、BPRS、PNSS精神病评定量表对治疗效果进行评定。结果依据减分率标准,18例患者中,显著进步12例,进步5例,无变化1例。手术前后量表评分有显著差异(P(0.05)。无智商损害等严重并发症和后遗症发生。结论多靶点定向毁损治疗难治性精神病失败后,再次手术仍效果显著。更多还原

【Abstract】 Objective To study the defeat reason of the first surgery and the curative effect of the second intractability psychosis in using of mutiple target and stereotactic surgery. Methods 18 patients were treated by stereotactic technique connect with bilateral multiple nuclei lesion, surgery effect were unsatisfactory, analysis reason.The second surgery treatment by stereotactic technique connect with bilateral multiple nuclei lesion and refers to the first surgery target and the present core symptom. The therapeutic effects were estimated with CGI、BPRS、PNSS and WISC. Results There are significance different in measuring scale between the second preoperative and postoperative (p<0.05).Based on the code of decreased rate,12 patients were respectively improved, 5 patients were improved and 1 patients were invalid, no intelligence quotient,complication and sequela taken occurrenced. Conclusion The curative effect of the second intractability psychosis in use of mutiple target and Stereotactic surgery is remarkable更多还原