【摘要】 目的探讨肿瘤标记物P504s在不同前列腺组织中的表达情况,及在诊断前列腺癌中的应用价值。方法采用免疫组化二步法,观察P504s和基底细胞标记物p63在不同前列腺病变组织中的表达情况。结果①P504s表达在前列腺癌根治标本、高等级上皮内瘤标本、前列腺增生标本中的阳性率分别为91.4%(32/35)、87.0%(20/23)和0(0/30),良恶性组织的差别有显著性,在前列腺癌穿刺标本中阳性率85.7%(72/84)。p63染色在全部前列腺癌中呈阴性,在高等级上皮内瘤中为不连续或连续的阳性染色,在前列腺增生中为连续的阳性染色。②P504s表达与前列腺癌的分化程度、激素治疗、转移有关。结论P504s是一个特异的前列腺癌标记物,结合p63在鉴别诊断前列腺癌中有重要的临床应用价值。更多还原

【Abstract】 Objective To investigate the expression and diagnostic utility of P504s in prostatic lesions.Methods Expressions of P504s and p63 in benign and malignant prostatic lesions were observed by immunohistochemical staining.Results ① The P504s staining was positive in 91.4%(32/35) cases of prostate cancer and 87.0%(20/23) cases of high-grade prostatic intraepithelial neoplasia(HGPIN) in radical prostatectomy specimens,but negative in all of the benign prostatic hyperplasia(BPH).85.7%(72/84) cases of prostate cancer in biopsy specimens were positive staining.In addition,the p63 staining was negative in prostate cancer and interruptedly or continuously positive in HGPIN,but positive in BPH.② The expressing of P504s was correlated to the tumor pathological grade,hormonal therapy and metastasis.Conclusion P504s is a specific biomarker for prostate cancer,and P504s/p63 immunostains are an important method for the diagnosis of prostate cancer.更多还原