【摘要】 目的研究¹³¹I治疗青少年甲状腺机能亢进的可行性和疗效,寻找一种治疗青少年甲亢的有效方法。方法回顾性分析53例经¹³¹I治疗的青少年Graves病患者,年龄14～20岁,平均16.5岁,甲状腺平均重量约为48g,其中合并Graves眼病21例,心律不齐伴心脏轻度扩大3例,并发周期性麻痹及重症肌无力7例,并发精神分裂症2例。嘱患者停用抗甲状腺药物和含碘食物至少2周,根据计算,空腹一次性口服一定剂量的¹³¹I,治疗后随访观察甲状腺激素水平等至少2年以上,评价疗效。结果53例青少年Graves病患者治愈29例（54.7%）,好转17例（32.0%）,一过性甲低7例（13.2%）。¹³¹I治疗眼病痊愈12例（57.1%）,好转6例（28.6%）,无效1例（4.8%）。结论¹³¹I可迅速治疗Graves病,有利于青少年智力和体格发育,治疗中服¹³¹I剂量应个体化,尽量减少甲低的发生率,可根治青少年Graves病。更多还原

【Abstract】 Objective To study the feasibility and curative effect of ¹³¹Iodine therapy for youngsters with Graves disease.Methods Fifty-three youngsters with Graves disease were enrolled,their ages were between 14 and 20, the average quality of their thyroids was 48g.All patients were told not to take anti-thyroid drugs for 2 weeks.Then cer- tain dose of ¹³¹I was taken with drink.The curative effect was evaluated by observing the patients’thyroid hormone level after ¹³¹I-taken.Results Twenty-nine（54.7%）patients were cured,17（32.0%）were much better than before and 7 （13.2%）were temporary hypothyroid.Among 21 patients with Graves ophthalmopathy,12（57.1%）were cured,6（28. 6%）were better,only 1（4.8%）of them was invalid.Conclusion ¹³¹I-taken can cure Graves disease much earlier than anti-thyroid drugs for youngsters.It’s beneficial to the development of youngsters’mentality and body development. Physicians should individualize the dose of ¹³¹I for each patient according to different condition.更多还原