【摘要】 目的:探讨糖化血红蛋白(HbA1C)在抗精神病药治疗中对血糖变化的监测作用。方法:对198例单用氯丙嗪或利培酮治疗的精神分裂症住院患者于治疗前、治疗1、2、3、6、12个月测定HbA1C及血糖浓度并与常规血糖检测指标进行比较。结果:HbA1C浓度随治疗时间延长而增高,与血糖浓度变化呈显著正相关,与血葡萄糖调节受损(IGR)的发生呈平行发展,治疗1年后异常率为11.6%。结论:HbA1C检测稳定性好,结合空腹血糖等常规指标,是抗精神病药治疗中观察血糖变化的有效指标。更多还原

【Abstract】 Objective: To explore the monitor role of glycohemoglobin (HbA1C) in the treatment of antipsychotics. Method:198 inpatients with schizophrenia were divided randomly into chlorpromazine group and risperidone group.HbA1C and fasting plasma glucose were tested before treatment and at 1,2,3,6,12 month after treatment, and compared with clinical routine fasting plasma glucose test. Results:The level of HbA1C trended to increase with the time of hospitalization and associated with the level of fasting plasma glucose and the incidence of imparied glucose regulation (IGR),whose abnormality rate was 11.6% one year after treatment. Conclusion:HbA1C can monitor IGR earlier,and is an efficacy index to the possible hyperglycemia in the treatment of antipsychotics when combined with routine fasting plasma glucose test.更多还原