【摘要】 目的利用血氧水平依赖性磁共振脑功能成像(BOLD-fMRI)技术观察运动中枢病变患者治疗前后的中枢激活体积的变化,探讨fMRI定量分析对揭示正常脑功能区激活特点和临床康复治疗评价的应用价值。资料与方法选择15例脑部疾病患者作为病例组和20名健康志愿者作为对照组进行运动中枢的fMRI研究,病例组分别于治疗后1~14天、1个月、3个月进行复查。结果20名正常人右手与左手、左手与双手对指运动所引起的脑功能区激活体积差异无统计学意义(P>0.05)。15例运动中枢病变组治疗1个月前后脑激活体积差异有统计学意义(P<0.05),治疗后1~14天激活体积值增幅较快,之后上升幅度变慢;6例治疗后1个月与治疗后3个月激活体积差异无统计学意义。结论(1)中枢激活区的体积可由AFNI软件精确计算出来,从而可观察正常人的中枢激活特点,评估患者的疾病康复情况及治疗效果;(2)病变治疗前后的激活体积随病情变化而相应变化,大致趋势是:病变激活体积小于正常人,治疗后短期(1~14天)复查显示激活区体积较治疗前明显增大,而随时间的推移,中枢激活体积增幅趋缓。更多还原

【Abstract】 Objective To observe change of the active volume of motor cortex with bold oxygenation level dependent functional magnetic resonance imaging(BOLD-fMRI)quantitatively,and evaluate normal motor cortex active characteristics in rehabilitation therapy of diseases involving motor cortex in pre and post therapy.Materials and Methods 15 patients of motor cortex lesion,20 normal volunteers as control group,were performed fMRI,following up in patient group after therapy in 1～14 days,1 month and 3 months.Results Motor cortex active volume on fMRI in control group appeared no significant differences between right hand and left hand,left hand and both hands motor mode(P>0.05).Motor cortex active volume on fMRI in patient group showed increment among 1 month pre and post therapy with significant differences(P<0.05).The motor cortex active volume on fMRI increased sharply in 1～14 days while slowly increased after 1 and 3 months therapy.There were no significant differences in motor cortex active volume after 1 and 3 months therapy.Conclusion The fMRI can show change of activated cortex volume and their distribution characteristics,and evaluate quantitatively rehabilitation therapy of diseases involving motor cortex.The activated cortex volume after therapy in primal 1～14 days is significant larger than that before therapy.As time goes on,the cortex activated volume will become larger,while their lesion volume is lower than the normal.7～14 days after therapy is the best rehabilitation time for patients with motor cortex lesion to improve nervous system.更多还原